Pyrrolidine and Putrescine Metabolism: γ-Aminobutyraldehyde Dehydrogenase
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چکیده
منابع مشابه
Pyrrolidine and Putrescine Metabolism: y-Aminobutyraldehyde Dehydrogenase
A strain of Pseudomonas Jluorescens (ATCC 13430) was isolated which could utilize either pyrrolidine or putrescine as the sole source of carbon, nitrogen, and energy for growth. An investigation of the metabolism of pyrrolidine by this organism (1) suggested Al-pyrroline (I) as the first product of pyrrolidine catabolism followed by y-aminobutyric acid (III). Enzymes which were induced by growt...
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Putrescine as the sole carbon source requires a novel catabolic pathway with glutamylated intermediates. Nitrogen limitation does not induce genes of this glutamylated putrescine (GP) pathway but instead induces genes for a putrescine catabolic pathway that starts with a transaminase-dependent deamination. We determined pathway utilization with putrescine as the sole nitrogen source by examinin...
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Enzyme purification and characterization, cDNA cloning and Northern blot analysis were the techniques utilized during this investigation to determine the identity and occurrence of the aldehyde dehydrogenase that metabolizes gamma-aminobutyraldehyde in adult human brain. The purification yielded one major protein which was active with gamma-aminobutyraldehyde. It had the physico-chemical and ki...
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The degradation of agmatine to succinate by Klebsiella aerogenes occurs in five steps. The enzyme catalyzing the first step, agmatinase, is induced by agmatine. The enzymes catalyzing the second and third steps, putrescine aminotransferase and 4-aminobutyraldehyde dehydrogenase, are induced by putrescine and also by their product, 4-aminobutyrate. The enzymes catalyzing the fourth and fifth ste...
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Putrescine was first isolated from putrifying meat and was thought of as a decomposition product; spermine was named from its occurrence in semen. These polyamines, however, are now known to have important roles in cell growth and differentiation. Their physiological significance can be studied by analyzing the consequences of depletion of the cellular polyamine content. The results include arr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1959
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)69882-5